A powerful tool for the detection of counterfeit drugs
ثبت نشده
چکیده
Drug formulation, an integral step in the regulated pharmaceutical industry, involves the careful blending and processing of precisely specified and measured components to create a final product that can be administered to deliver the required clinical dose. The production of counterfeit drugs is a major challenge to the industry and has the potential to endanger health, threaten reputation and, in the long-term, reduce the funds needed to drive pharmaceutical innovation. Counterfeit products, although often packaged convincingly, may have specific components replaced or altogether removed, and/or additional components included. Investigation of the composition of illegal drugs provides insight into their provenance to criminalists working in this area. However, it can be difficult to robustly detect and identify fake actives, contaminants and/or bulking agents, hampering efforts to investigate the associated crimes. Tracking down and halting counterfeiting operations is a substantial and complex activity and calls for highly effective analytical strategies.
منابع مشابه
Iranian Pharmacists’ Knowledge, Attitude and Practice Regarding Counterfeit Drugs
Background Awareness of pharmacists about counterfeit drugs is necessary for health improvement in community. The purpose of the present study is to assess the knowledge and measure the professional attitude and practice of Iranian pharmacist about counterfeit drugs. In August 2008, a knowledge, attitude and practice (KAP) study was performed in a national sample of 794 pharmacists who particip...
متن کاملIranian Pharmacists’ Knowledge, Attitude and Practice Regarding Counterfeit Drugs
Background Awareness of pharmacists about counterfeit drugs is necessary for health improvement in community. The purpose of the present study is to assess the knowledge and measure the professional attitude and practice of Iranian pharmacist about counterfeit drugs. In August 2008, a knowledge, attitude and practice (KAP) study was performed in a national sample of 794 pharmacists who particip...
متن کاملDetecting counterfeit antimalarial tablets by near-infrared spectroscopy.
Counterfeit antimalarial drugs are found in many developing countries, but it is challenging to differentiate between genuine and fakes due to their increasing sophistication. Near-infrared spectroscopy (NIRS) is a powerful tool in pharmaceutical forensics, and we tested this technique for discriminating between counterfeit and genuine artesunate antimalarial tablets. Using NIRS, we found that ...
متن کاملThe health and economic effects of counterfeit drugs.
BACKGROUND Counterfeit drugs comprise an increasing percentage of the US drug market and even a larger percentage in less developed countries. Counterfeit drugs involve both lifesaving and lifestyle drugs. OBJECTIVE To review the health and economic consequences of counterfeit drugs on the US public and on the healthcare system as a whole. METHOD This comprehensive review of the literature ...
متن کاملQuantitative bioassay to identify antimicrobial drugs through drug interaction fingerprint analysis
Drug interaction analysis, which reports the extent to which the presence of one drug affects the efficacy of another, is a powerful tool to select potent combinatorial therapies and predict connectivity between cellular components. Combinatorial effects of drug pairs often vary even for drugs with similar mechanism of actions. Therefore, drug interaction fingerprinting may be harnessed to diff...
متن کامل